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CHRONICALLY IMPLANTABLE HYBRID CANNULA-MICROELECTRODE SYSTEM FOR CONTINUOUS MONITORING ELECTROPHYSIOLOGICAL SIGNALS DURING INFUSION OF A CHEMICAL OR PHARMACEUTICAL AGENT
CHRONICALLY IMPLANTABLE HYBRID CANNULA-MICROELECTRODE SYSTEM FOR CONTINUOUS MONITORING ELECTROPHYSIOLOGICAL SIGNALS DURING INFUSION OF A CHEMICAL OR PHARMACEUTICAL AGENT
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机译:插拔式混合插管-微电极系统,用于在注入化学或药物制剂过程中连续监测电生理信号
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摘要
A device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons allows for the infusion of reagents through a cannula located among an array of microelectrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical “signatures” of therapeutically useful drugs.
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