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Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
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机译:通过精氨酸化和N端规则途径的特异性调控来通过一氧化氮信号传导调节一氧化氮
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摘要
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-end rule pathway mediated arginylation.
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