(2S, 3R) - N - (2 - (3-pyridinyl) methyl) - 1-azabicyclo (2.2.2 = Aug - 3 - il) benzofuran - 2 - carboxamide forms salts, and Methods of use

摘要

Production Procedure of trazodone and trazodone hydrochloride which comprises the steps of: (a) preparing an organic Phase comprising at least a trazodone in Organic Solvent; (b) preparing an aqueous Phase comprising at least a basic compound; (c) B. Ar the aqueous phase to the Organic Phase; (d) heated to a temperature of at least 40sc DurantAnd at least 30 minutes; (e) to recover the trazodone; and optionally (f) treat the trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a Pharmaceutical composition comprising Said trazodone hydrochloride.