vaccines for rapid response to avian influenza pandemic

摘要

Vaccines for the rapid response to the avian influenza pandemic. The present invention relates to adenovirus-based vaccines against pandemic potential avian influenza viruses. The present invention provides defective replication adenoviral vectors each having a nucleic acid encoding an influenza A polypeptide. When introduced into an individual the expressed influenza A polypeptide induces the production of influenza-binding antibodies. The present invention also provides methods for inducing an immune response in an individual. Defective replication adenoviral vector is administered to individuals, wherein the vector has a nucleic acid encoding an influenza A polypeptide. When the vector is expressed in the individual, influenza A polypeptide induces the subject to produce antibodies to influenza.