A METHOD OF EX-VIVO PROMOTING OSTEOGENESIS OR DIFFERENTIATION OF A CELL INTO AN OSTEOBLAST

摘要

ABSTRACT 2818/CHENP/2005 "A method of ex-vivo promoting osteogenesis or differentiation of a cell into an osteoblast" The present invention relates to a method of ex-vivo promoting osteogenesis or differentiation of a cell into an osteoblast, the method comprising contacting the cell ex vivo with a nucleic acid agent capable of abrogating or diminishing an expression of TAK1 in the cell, thereby regulating the activity of the SMAD protein in the cell to thereby ex vivo promote osteogenesis or differentiation of the cell into an osteoblast.