首页>
外国专利>
CHEMOKIN-MUCIN FUSION PROTEINS WITH A GPI ANCHOR DOMAIN AND THEIR USE AS TUMOR IMMUNAL ADJUVANCIA OR IN TISSUE GENERATION
CHEMOKIN-MUCIN FUSION PROTEINS WITH A GPI ANCHOR DOMAIN AND THEIR USE AS TUMOR IMMUNAL ADJUVANCIA OR IN TISSUE GENERATION
展开▼
机译:具有GPI锚定域的化学-黏蛋白融合蛋白及其在肿瘤,advuvancia或组织产生中的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to chemokine-mucin fusions linked to glycosylphosphatidylinositol (GPI)-anchors and their use as anti-cancer adjuvants and as agents in tissue regeneration and suppression of vascular damage. GPI-linked chemokines are incorporated in the surface membrane of tumour cells and effect a recruitment of cytotoxic immune cells to the tumour site following injection in vivo. Leukocytes, cytotoxic T-cells and NK cells target the chemokine-GPI-anchored tumour cells and modulate cell-mediated lysis of the tumour cells. The efficiency of GPI-anchoring and modulation of immune cells can be further enhanced by linking the chemokine to a mucin domain followed by the GPI-anchor. The GPI-anchored chemokines, with or without mucin domain, are remarkably useful for the inhibition of tumour growth, tissue regeneration, and suppression of acute vascular damage to allografts.
展开▼