Procedure for the detection of pathological states in humans through the realization of a morphometric-geometric analysis of relative deformations in protein maps. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the detection of pathological states in humans by performing a morphometric-geometric analysis of relative deformations in protein maps. The present invention relates to the development and application of a methodological procedure for detecting changes in the position of proteins, resolved by two-dimensional gel electrophoresis, which are representative of variations in the isoelectric point and/or relative molecular mass of the proteins studied, through the analysis carried out through a morphometric-geometric method. The detection of a determined pattern of changes in a biological sample allows distinguishing healthy individuals from patients of a certain pathology, by means of a simple study of their protein map. From a clinical point of view, this technique allows to diagnose pathological states, predict the evolution of a patient, or make decisions about the suitability of a treatment, comparing the electrophoretic pattern of the altered state with the representative of a healthy state. (Machine-translation by Google Translate, not legally binding)