The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and meth-odsin which the dyes are conjugated to substrates and used as detection labels inmolecular biology experiments. Theelectron-de-ficient nitrogen heterocycles include pyridine, quinoline,pyrazine, and the like. Substrates include polynucleotides, nucleosides,nucleotides, peptides, proteins, carbohydrates, and ligands.
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