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MXA AS AN ANTIVIRAL DRUG AND AS A TARGET FOR IDENTIFICATION OF ANTIVIRAL DRUGS FOR DNA VIRUS INFECTIONS
MXA AS AN ANTIVIRAL DRUG AND AS A TARGET FOR IDENTIFICATION OF ANTIVIRAL DRUGS FOR DNA VIRUS INFECTIONS
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机译:MXA作为一种抗病毒药物,也是一种识别DNA病毒感染的抗病毒药物的目标
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摘要
The invention features methods and compositions for use in a screening assay to identify agents having antiviral activity against a DNA virus by assessing the effect of a candidate agent upon alternative splicing of MxA, or by assessing the effect of a candidate agent on production of a variant form of MxA protein. The invention also provides methods for enhancing resistance of cells to infection by a DNA virus by providing for elevated MxA and/or by providing for reduced production of variant MxA protein.
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