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PREVENTION AND TREATMENT FOR OSTEONECROSIS AND OSTEORADIONECROSIS OF THE JAW USING PDGF AND A BONE MATRIX
PREVENTION AND TREATMENT FOR OSTEONECROSIS AND OSTEORADIONECROSIS OF THE JAW USING PDGF AND A BONE MATRIX
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机译:用PDGF和骨基质预防和治疗颌骨骨骨愈合和骨桥骨愈合。
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摘要
The present invention provides compositions and methods useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer wherein the PDGF is disposed in a biocompatible matrix in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. In one embodiment, a method for treating, preventing or slowing the progression of ONJ or ORNJ comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to a desired site in the jaw. In another embodiment, a method for treating, preventing or slowing the progression of ONJ or ORNJ comprises providing a composition comprising a PDGF in a pharmaceutically acceptable buffer and applying the composition to a desired site in the jaw. The present invention also provides kits useful for treating, preventing or slowing the progression of ONJ and ORNJ.
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