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CONJUGATE FOR THE SPECIFIC TARGETING OF ANTICANCER AGENTS TO CANCER CELLS AND PRODUCTION THEREOF
CONJUGATE FOR THE SPECIFIC TARGETING OF ANTICANCER AGENTS TO CANCER CELLS AND PRODUCTION THEREOF
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机译:结合抗癌剂对癌细胞的特定靶向及其生产
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摘要
A conjugate is disclosed herein, wherein the conjugate comprises a ligand having the ability to bind to a receptor, wherein the receptor is overexpressed on a surface of a cancer cell, and an anticancer agent selectively toxic to cancer cells coupled to the ligand. The anticancer agent may be L-methioninase. Pharmaceutical compositions comprising the conjugate are also disclosed. A method of inducing tumor cell death in vivo is also disclosed and includes contacting a population of tumor cells in vivo with a therapeutically effective amount of the conjugate.
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