A BIOSENSOR DEVICE AND A METHOD OF SEQUENCING BIOLOGICAL PARTICLES

摘要

A biosensor device (100) for sequencing biological particles (102), the biosensor device (100) comprising at least one substrate (104), a plurality of sensor active regions (106) provided on each of the at least one substrate (104) and each comprising a primer (108) having a sequence being complementary to a part of a sequence of the biological particles (102) and enabling generation of fragments having a sequence being inverse to a part ofthe sequence of the biological particles (102) at the primer(108), and a determination unit (114) adapted for individually determining a size of the fragments generated at the primer (108) of each of the plurality of sensor active regions (106), the fragment replication being terminated in the presence of replication terminating sequence units (116 to 119).