METHODS FOR DIAGNOSING EPIGENETIC, TRANSGENERATIONAL EFFECTS OF ENVIRONMENTAL TOXICANTS ON MAMMALIAN GERM-LINES AND TREATING ASSOCIATED DISEASES

摘要

The present invention provides methods for detecting epigenetic, multigenerational DNA alterations caused by toxicants such as endocrine disruptor agents in a subject. The practice of the present invention can be used to diagnose and/or treat a subject having the identified DNA alterations by developing therapeutics, to prevent or delay the onset of associated diseases and/or dysfunctions.