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MUCOSALLY NON-IRRITATIVE LIQUID AMPHOTERICIN B FORMULATIONS AND METHODS FOR TREATING NON-INVASIVE FUNGUS-INDUCED MUCOSITIS
MUCOSALLY NON-IRRITATIVE LIQUID AMPHOTERICIN B FORMULATIONS AND METHODS FOR TREATING NON-INVASIVE FUNGUS-INDUCED MUCOSITIS
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机译:粘膜非刺激性两性霉素B制剂和治疗非侵入性真菌诱发的粘膜炎的方法
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摘要
The present invention is directed to liquid compositions and methods for non-irritatively treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves liquid compositions including a mucosally non-irritative mixture of amphotericin B and a pharmaceutically acceptable carrier. Such compositions can be non-irritatively mucoadministered to prevent, reduce, or eliminate chronic non-invasive fungus-induced mucositis conditions. In some embodiments, the compositions are stored in a sealed container under an inert gas atmosphere (e.g., nitrogen) prior to mucoadministration, which provide enhanced stability. Other aspects of the invention are sealed containers containing a liquid composition comprising a mucosally non-irritative mixture of amphotericin B; a pharmaceutically acceptable carrier; and an inert gas headspace, such as pure, medical grade nitrogen.
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