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Soluble amyloid precursor proteins in cerebrospinal fluid as biomarkers of Alzheimer's disease
Soluble amyloid precursor proteins in cerebrospinal fluid as biomarkers of Alzheimer's disease
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机译:脑脊液中的可溶性淀粉样蛋白前体蛋白可作为阿尔茨海默氏病的生物标记
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摘要
An ex vivo method of diagnosing Alzheimer's disease comprising the steps of analysing a cerebrospinal fluid (CSF) sample taken from a patient with regard to a concentration of at least one amyloid precursor protein (APP) product selected from the group consisting of soluble forms of amyloid precursor protein α and β (sAPPα and sAPPβ); comparing the concentration of the at least one APP product with a threshold-value for the concentration of the respective one APP product; and indicating a probability that the patient has or is prone to Alzheimer's disease, if the concentration of the at least one APP product exceeds the threshold-value for the concentration of the respective one APP product.
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