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SYNTHESIS OF FLEMICHAPPARIN A, FLEMINGIN A, FLEMINGIN D AND THEIR ANALOGUES
SYNTHESIS OF FLEMICHAPPARIN A, FLEMINGIN A, FLEMINGIN D AND THEIR ANALOGUES
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机译:氟卡帕林A,弗林明A,弗林明D的合成及其类似物
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摘要
A method for synthesizing flemichapparin A, flemingin A, flemingin D and their derivative is provided to development simple and efficient synthesis process of pyranochalcones. A method for synthesizing a natural flemichapparin A comprises: a step of reacting 2,4,5-trihydroxyacetophenone and 3-methyl-2-buthenal in a toluene under the presence of 10 %mole of ethylenediamine diacetate for 12 hours to produce the compound of the chemical formula 15; a step of reacting one equivalent of MOMCL with the compound of the chemical formula 15 under the presence of diisopropylethylamine in methylenechloride for 10 hours to produce a compound of the chemical formula 16; a step of reacting the compound of the chemical formula 16 with benzaldehyde of the chemical formula 17 for 48 hours to produce a compound of the chemical formula 20; and a step of reacting the compound of the chemical formula 20 with 3N hydrochloric acid to produce the flemichapparin A of the chemical formula 1.
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