Development of a binding assay and presentation of novel inhibitors of the myelin associated glycoprotein

摘要

If accidents or diseases lead to injuries of the adult central nervous system, the affected body functions are generally permanently restricted or lost. Due to the lack of ability to regenerate the central nervous system and the brain, this is irreversible in almost all cases.1 For those affected, the resulting loss of motor function and normal body functions, such As the control of the bladder and rectum, extreme restrictions in everyday life. In addition, in the paralyzed areas the perception of pain and the temperature and tactile sensation is lost. Paraplegics are often no longer able to cope with their everyday lives alone. In Germany, about 1000 new cases of paraplegia occur each year. For the US, the National Spinal Cord Injury Association (NSCIA) lists 11,000 new cases of Spinal Cord Injury (SCI) per year. 80% of those affected are men. The most common causes of SCI are vehicle accidents at 47.5% and falls at 22.9% .2 In contrast to the central nervous system (CNS), the peripheral nervous system (PNS) is capable of regeneration after injury. The nervous connections can usually be completely restored here while retaining the functions. This fact can be exploited to explore which differences in PNS to CNS allow for this regeneration. It could be found ways to ...