首页>
外国专利>
REVIEW METHODS FOR REACTIONS REGULATING THE INHIBITOR-OF-APOPTOSE PROTEIN (IAP) AND THEREOF IMPACTING ON CASPASE ACTIVITY
REVIEW METHODS FOR REACTIONS REGULATING THE INHIBITOR-OF-APOPTOSE PROTEIN (IAP) AND THEREOF IMPACTING ON CASPASE ACTIVITY
展开▼
机译:调节凋亡抑制蛋白(IAP)及其对Caspase活性的影响的综述方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP and a caspase. In addition, the invention provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP and further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
展开▼