首页> 外国专利> Cell introduction agent, cell introduction method, method for producing cell introduction agent, composition for producing cell introduction agent, and kit for producing cell introduction agent

Cell introduction agent, cell introduction method, method for producing cell introduction agent, composition for producing cell introduction agent, and kit for producing cell introduction agent

机译:细胞导入剂,细胞导入方法,细胞导入剂的制造方法,细胞导入剂的组合物及细胞导入剂的制造试剂盒

摘要

The present invention provides a delivery agent having superior reproducibility and biocompatibility that allows a target substance to be efficiently delivered to cells. In a delivery agent comprising compound particles of DNA and a calcium phosphate-based material, the release time of DNA inside a cell can be controlled to realize efficient cell transfection by adjusting the dissolution rate of the compound particles relative to pH so that at least 50% of the compound particles present at pH 8.0 dissolve within a predetermined time after changing the pH to 6.0.
机译:本发明提供了具有优异的再现性和生物相容性的递送剂,其允许将靶物质有效地递送至细胞。在包含DNA化合物颗粒和磷酸钙基材料的传递剂中,可以通过调节化合物颗粒相对于pH的溶出度至至少50来控制细胞内DNA的释放时间,以实现有效的细胞转染。在pH值改变为6.0后的预定时间内,pH值为8.0的化合物颗粒的100%溶解。

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