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INFECTIOUS cDNA CLONE OF THE MODIFIED LIVE VIRUS VACCINE STRAIN OF EQUINE ARTERITIS VIRUS

机译：改良活马病毒活病毒疫苗株的感染cDNA基因克隆。

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摘要

An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ ID NO:1 or a degenerate variant thereof. Also provided are transformed or transfected host cells including that sequence, vectors including the sequence, and isolated infectious RNA molecules encoded by the sequence. Further, a modified DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus is provided wherein the DNA sequence is SEQ ID NO:2 or a degenerate variant thereof, including a si lent point mutation allowing distinguishing the modified sequence from the parent and other strains of Equine arteritis virus.

机译：分离的多核苷酸分子包括编码感染性RNA分子的DNA序列，该感染性RNA分子编码马动脉炎病毒的修饰的活病毒株，其中该DNA序列是SEQ ID NO：1或其简并变体。还提供了包括该序列的转化或转染的宿主细胞，包括该序列的载体以及由该序列编码的分离的感染性RNA分子。此外，提供了编码感染性RNA分子的修饰的DNA序列，所述感染性RNA分子编码马动脉炎病毒的修饰的活病毒株，其中所述DNA序列是SEQ ID NO：2或其简并变体，包括允许区分所述修饰的来自马动脉炎病毒的亲本和其他菌株的序列。

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公开/公告号US2010221826A1

专利类型
公开/公告日2010-09-02

原文格式PDF
申请/专利权人 UDENI B.R. BALASURIYA;PETER J. TIMONEY;JIANQIANG ZHANG;
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申请/专利号US20090436242
发明设计人 UDENI B.R. BALASURIYA;JIANQIANG ZHANG;PETER J. TIMONEY;
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申请日2009-05-06
分类号C12N5/10;C07H21/04;C12N15/63;C07H21/02;
国家 US
入库时间 2022-08-21 18:53:33

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