Genetically Altered Anti-body Producing Cell Lines With Improved Antibody Characteristics
展开▼
机译:具有改进的抗体特性的基因改造的抗体生产细胞系
展开▼
页面导航
摘要
著录项
相似文献
摘要
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. Cells may be selected for expression of activation-induced cytidine deaminase (AID), stimulated to produce AID, or manipulated to express AID for further enhancement of hypermutability. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production.
展开▼