Bivalent antibodies include (a) a light, heavy chain that binds to the first antigen.(b) A light and heavy chain is combined with the second antigen, in which CL and CH1 domain names are exchanged.In addition, the CH3 domains of these two heavy chains are altered by substituting amino acid residues.Therefore, one of the CH3 mutations occurs.And a hole in another CH3,Preparation of this antibody3. Huesped cells containing the antibody encoding vector;There are also works that can be understood.

摘要

Bioespecu00edfico Bivalent Antibody heavy and light chain comprising an Antibody that binds to an AntigenAnd the Light and heavy chain of Antibody that binds to a Second AntigenThe Constant CL and CH1 Domains are for one another; Preparation method; host Cell; and composition.