N - (2 - hydroxyethyl) - N - methyl - 4 - (quinolin-1 (IL - 8 - 1 - (tiazn - (2 - hydroxyethyl) - N - methyl - 4 - (quinolin-1 (IL - 8 - 1 - (4 - Methyl thiazole - ylidene) piperidin-4-yl) methyl) benzamide EOL - 4 - ylmethyl) piperidin-4-yl ylidene) methyl) benzamide process for its Synthesis and its use in the process for their Synthesis and their use for e L Treatment of Pain, Anxiety and Depression Treatment of Pain, Anxiety and Depression

摘要

1.- N- (2-hydroxyethyl) -N-methyl-4- (quinolin-8-yl (1- (1.- N- (2-hydroxyethyl) -N-methyl-4- (quinolin-8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamithiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide, its pharmaceutically acceptable salts or its mda, its pharmaceutically acceptable salts or mixtures thereof. 2.- N- (2-hydroxyethyl) -N-methyl-4- (quinolin-ezclas. 2.- N- (2-hydroxyethyl) -N-methyl-4- (quinolin-8-yl (1- (thiazole -4-ylmethyl) piperidin-4-ylidene) methy8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide 3.- A pharmaceutical composition that l) benzamide. 3. A pharmaceutical composition comprising a compound according to the claim comprises a compoundO under claim 1 or 2, a pharmacist may accept 1 or 2, and a pharmacist may accept a holder. 4. Preparation of N - (2-hydroxy) process. 4. - N - (2-hydroxy) n-methyl-4 - (piperidin-4-iden-quinlin-8-ilmeti) - n-methyl-4 - (piperidin-4-iden-quinlin-8-ilmetl) benzene zamida preparation process, including: reaction 4 - (bromine) benzene zamida, including: reactionr a 4- (bromo- {4 - [(2-hydroxyethyl) methylcarbamoyl] phenyl} methylene- {4 - [(2-hydroxyethyl) methylcarbamoyl] phenyl} methylene) piperidine protected with 8-quinolinboronic acid) acid-protected piperidine 8 -quinolinboronic to form an N- (2-hydroxyethyl) -N-methyl-4- (pipe to form an N- (2-hydroxyethyl) -N-methyl-4- (piperidin-4-ylidenoquinolin-8-ylmethyl) benzamide Protegridin-4-ylidenoquinolin-8-ylmethyl) protected benzamidey desproteger dicha N- (2-hidroxietil) -N-metilida y desproteger dicha N- (2-hidroxietil) -N-metil-4- (piperidin-4-ilidenoquinolin-8-ilmetil) benzamid-4- (piperidin-4 (o) Protected pyridine, including: 2 - (methylamine) ethanol and 4 - [bromine - (4-amino) ethanol and 4 - [bromine - (4-amino) ethanol and 4 - [bromine - (4-amino) toluene] protected pyridine. 6. A protected nil (methyl) pyridine process. 6. - N - (2-hydroxy) - n-methyl-4 - (n - (2-hydroxy) - n-methyl-4 - (piperidin-4-ilideoquinlin-8-ilmeth) triphenylbenzodiazepine1. The protected amphetamine type stimulants include: 4 - (bromine - {4 - {2gida, including: 4 - (bromine - {4 - {2 - {hydroxy}) methylamino) phenyl (RN ethylene); (methylhydroxy) phenyl (rnetline)), phenyl (rnetline) pyridine protected by 8-quinnediol acid. 7. - use 8-quinic acid to protect Idina. 7. Procedures meeting qualification requirements 66. The process in the sixth requirement also includes the reaction of 4 - (bromine - {4 - [(2-Hi) and 4 - (bromine - {4 - [(2-hydroxy) methylamino) phenyl (methylene) pyridine hydroxy) methylaminomethanol] phenyl toluene, which is protected by 8-quinic acid and keeps consistent with the acid.O 8-quinnediol can form n - (2-hydroxy) n-methyl-4 - (piperidin-4-ilar una n - (2-hydroxy) - n-methyl-4 - (piperidin-4-ideoquinlin-8-ilmetl) benzene zamida which is protected. 8. - eidenokolin-8-ilmetr) benzamida is protected. 8. Procedures to meet requirements71. Procedures under claim 7, including, but not including, the protection of N - (2-hydroxy) (2-hydroxy) and the protection of N - (2-hydroxy) (n - (piperidin-4-ilidinoquinlin-8-ilmetl) - n-methyl-4 - (piperidin-4-ilidinoquinlin-8-ilmetl) - protected benzene zamida to form n - (2-hydroxy) B1. The protected n-amides can form n - (2-hydroxy) n-methyl-4 - (piperidin-4-ideoquinlin-8-ilmetl) - n-methyl-4 - (piperidin-4-ideoquinlin-8-ilmetl) benzene zamida. 9. Procedures related to reivl. 9. Satisfactory procedures8which further comprises reacting Nindication 8, which further comprises reacting N- (2-hydroxyethyl) -N-methyl-4- (piperidin-4-ylidenoqui- (2-hydroxyethyl) -N-methyl-4- (piperidin-4 -ylidenoquinolin-8-ylmethyl) benzamide with thiazol-4-carbaldehnolin-8-ylmethyl) benzamide with thiazol-4-carbaldehyde to form N- (2-hydroxyethyl) -N-methyl-4- (quinoid to form N- (2 -hydroxyethyl) -N-methyl-4- (quinolin-8-yl (1- (thiazol-4-ylmethyl) piperidin -4-ylideneolin-8-yl (1- (thiazol-4-ylmethyl) piperidin -4-ylidene ) methyl) benzamide.) methyl) benzamide.