CHIMERIC POLYPEPTIDE COMPRISING APOPTOSIS FACTOR, METHOD OF INDUCING THE SAME IN A CELL IN VITRO, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND USE THEREOF IN THE MANUFACTURE OF HYPERPROLIFERATIVE DISORDER TARGETING MEDICAMENT

摘要

The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.