USE OF A PEPTIDE DERIVED FROM ER-ALPHA FOR RESTORING SENSITIVITY TO ANTIESTROGENIC COMPOUNDS IN BREAST TUMOUR CELLS

摘要

The present invention relates to the use of a peptide having a sequence with at least 90% identity with SEQ ID NO: 1 for the preparation of a medicament for restoring sensitivity to antiestrogenic compounds in antiestrogenic-resistant breast tumour cells. A conjugate of the peptide of SEQ ID NO: 1 with a peptide vehicle selected from the group consisting of TAT, Antennapedia (Antp) and Model Amphipathic Peptide (MAP) is also provided.