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Method for uniformly labelled ligation detection reactions (LDRs) associated to universal arrays and labelled probes thus obtained
Method for uniformly labelled ligation detection reactions (LDRs) associated to universal arrays and labelled probes thus obtained
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机译:与通用阵列和由此获得的标记探针相关的统一标记的连接检测反应(LDR)的方法
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摘要
The invention relates to a method to circumvent the natural loss of fluorescence of fluorophores used to label LDR probes due to freezing/thawing cycles which often results in inconsistent and biased experiment outputs; the method is based on indirect labeling of LDR probes by the addition of universal sequences (ULS) which hybridize to fluorophore-labeled oligonucleotides with complementary universal sequences (cULS). The invention also relates to LDR DPs for LDR-UA assays, comprising ULS and labelled cULS.
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