首页>
外国专利>
METHOD FOR PRODUCING INJECTABLE PREPARATION CONTAINING CEFTRIAXONE SODIUM AND TAZOBACTAM SODIUM
METHOD FOR PRODUCING INJECTABLE PREPARATION CONTAINING CEFTRIAXONE SODIUM AND TAZOBACTAM SODIUM
展开▼
机译:包含头孢曲松钠和他唑巴坦钠的可注射制剂的制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method for producing injectable preparation containing ceftriaxone sodium and tazobactam sodium, involves the steps of: (a) weighing raw materials of ceftriaxone sodium, tazobactam sodium, sterile water for injection, the mixture of ethyl acetate and isopropyl alcohol, and anhydrous ethanol with the weight ratio of 3-5: 1: 2: 5: 9, wherein the volume ratio of ethyl acetate to isopropyl alcohol is 1: 2-4; (b) dissolving ceftriaxone sodium and tazobactam sodium in sterile water for injection, then adding activated charcoal and performing filtration; (c) adding the mixture of ethyl acetate and isopropyl alcohol to the filtrate and stirring them well, then adding ceftriaxone sodium crystal seed to the solution to crystallize, and finally washing the crystal with anhydrous ethanol and drying the crystal; and (d) freeze-drying to obtain injectable preparation containing ceftriaxone sodium and tazobactam sodium. The preparation has good uniformity, high purity and safety.
展开▼