PRODUCING METHOD OF IBUPROFEN ARGINATE AND (S)-IBUPROFEN AMINO ACID SALT CAPABLE OF IMPROVING THE BIOAVAILABILITY BY ENHANCING THE SOLUBILITY

摘要

PURPOSE: A producing method of ibuprofen arginate and (S)-ibuprofen amino acid salt is provided to improve the reaction yield without using ethanol or water, and to reuse a solvent without a separate process.;CONSTITUTION: A producing method of ibuprofen arginate and (S)-ibuprofen amino acid salt marked with chemical formula 1 or chemical formula 2 comprises the following steps: heating and stirring ibuprofen or (S)-ibuprofen inside a propanol solvent, and L-arginine; cooling the mixture and filtering a crystal; and drying the crystal.;COPYRIGHT KIPO 2011