A Block Copolymer of Polyethylene glycol-b-Poly-L-serine-g-PolyD,L-lactide And Nanoparticles For Drug Delivery Vector Using Thereof

摘要

The present invention is represented by the following structural formula , poly (D, L- lactide), poly having a side chain (ethylene glycol) - b - relates to a method for producing a poly (L- serine) cheyong nanoparticle drug delivery and using them in the synthesis of block copolymers, the novel poly (ethylene glycol) - b - [poly (L- serine) - g - poly (D, L- lactide)] to provide a copolymer of. According to the present invention, poly (L- serine) block of the copolymer is present at the interface between the hydrophobic core and a hydrophilic shell, the strong hydrogen bonding between the amide groups present in the chemical structure can be stabilized nanoparticles formed due to there. ; Structure ; wherein, m is an integer from 3 to 50, n is an integer of from 6 to 400. And x is an integer of 10 to 150.