COMPOUNDS WITH MEDICAL EFFECTS DUE TO INTERACTION WITH A GLUCCORTICOID RECEPTOR

摘要

1. The compound having the structure according to the formula I! ! where X represents a nitrogen or carbon atom; ! Ar represents a phenyl or heteroaromatic ring; ! R1 represents hydrogen, halogen, CN or (C1-C4) alkyl; ! R2 is hydrogen, halogen or optionally fluorinated (C1-C3) alkoxy; ! R3 and R5 independently represent hydrogen, optionally halogenated (C1-C4) alkoxy, optionally halogenated (C1-C4) alkoxy, optionally halogenated aryl (C1-C4) alkoxy, optionally halogenated (C1-C4) alkenyl or hydroxylmethyl; ! R4 is hydrogen, halogen, optionally halogenated (C1-C4) alkoxy or optionally halogenated aryl (C1-C4) alkoxy; ! R6 is hydrogen, benzyl optionally substituted with one or more halogen, or (C1-C4) alkyl, or R6 is optionally halogenated (C1-C4) alkyl; ! each R7 independently represents hydrogen, halogen, optionally halogenated (C1-C4) alkyl or optionally halogenated (C1-C4) alkoxy; ! or a pharmaceutically acceptable acid addition salt thereof. ! 2. The compound according to claim 1, where! X represents a nitrogen or carbon atom; ! Ar represents a benzene or heteroaromatic ring; ! R2 is halogen or optionally fluorinated (C1-C3) alkoxy; ! at least one of R3, R4 or R5 is hydrogen; ! R6 is hydrogen or methyl; ! or a pharmaceutically acceptable addition salt thereof. ! 3. The compound according to claim 1, where! Ar is thiazole, thiophene, isoxazole, furan or 1H-pyrazole; ! R1 represents hydrogen, halogen, CN or methyl; ! R2 is hydrogen, halogen or optional