TSIANOIZOHINOLINOVYE COMPOUND (VARIANTS) PHARMACEUTICAL COMPOSITION ON THEIR BASIS METHOD FOR INHIBITING ACTIVITY hydroxylase Hypoxia-Inducible Factor (HIF) and methods of treatment and / or prophylaxis of conditions associated with HIF and / or condition associated with erythropoietin and / or anemia

摘要

1. Cyanoisoquinoline compounds covered by the general structural formula I:! ! where R is selected from the group consisting of hydrogen, alkyl and substituted alkyl,! R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, cyano, hydroxy, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, -OR7, -SR7, -SOR7 and -SO2R7, where R7 is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl,! R5 and R6 are independently selected from the group consisting of hydrogen or C1-C3 alkyl,! or their pharmaceutically acceptable salts, tautomers, stereoisomers, solvates and / or prodrugs. ! 2. The compounds according to claim 1, in which at least two of R1, R2, R3 and R4 are hydrogen. ! 3. The compounds according to claim 1, in which R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, hydroxy, halogen, substituted alkyl, aryl, -OR7, -SR7 and -SO2R7, where R7 is selected from the group including alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl. ! 4. The compounds according to claim 3, in which R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, haloalkyl, alkyl, alkoxy, aryloxy and substituted aryloxy. ! 5. The compounds according to claim 3, in which R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, hydroxy, phenyl, chloro, trifluoromethyl, benzyl, benzyloxy, methoxy, butoxy, isopropoxy, phenoxy, 4-fluorophenoxy, 2 -methoxyphenoxy, 3-methoxyphenoxy, 4-methoxyphenoxy, 2,6-dimethylphenoxy, 2-ethyl-6-methylphenoxy, 2,4,6-trimethylphenoxy, 4-chloro-2,6-dimethylphenoxy, 4-propoxyphenoxy, 2,3 -dihydrobenzo-furan-5-yloxy, 2-methylbenzothiazol-6-yloxy, 2-dimethylaminobenzoxaz