AMINO-IMIDAZOLONES AND THEIR APPLICATION AS A MEDICINAL TREATMENT FOR THE TREATMENT OF COGNITIVE DISORDER, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA

摘要

1. The compound of formula I:! ! where A is independently selected from a 5-, 6- or 7-membered heterocyclic ring optionally substituted with one or more R1; ! B is phenyl optionally substituted with one or more R2; ! C is independently selected from phenyl or from a 5- or 6-membered heteroaromatic ring, optionally substituted with one or more R3; ! R1 is independently selected from halogen, cyano, nitro, OR6, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, C3-6 heterocyclyl, NR6R7, CONR6R7, NR6 (CO) R7, O (CO) R6, CO2R6, COR6, (SO2) NR6R7, NR6 (SO2) R7, SO2R6, SOR6, OSO2R6 and SO3R6, where indicated are C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3-6 cycloalkyl, C3-6 cycloalkenyl , C3-6 cycloalkynyl and C3-6 heterocyclyl may optionally be substituted with one or more D; ! each of R2, R3 and R4 is independently selected from halogen, cyano, nitro, OR6, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C0-6 alkylaryl, C0-6 alkylheteroaryl, C0-6 alkylC3-6 cycloalkyl, C0-6 alkylC3-6 cycloalkenyl, C0-6alkylC3-6cycloalkynyl, C0-6alkylC3-6heterocyclyl, NR6R7, CONR6R7, NR6 (CO) R7, O (CO) R6, CO2R6, COR6, (SO2) NR6R7, NR6 (SO2) R7, SO2R6 and SOR6, where indicated are C1 -6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylaryl, C0-6alkylheteroaryl, C0-6alkylC3-6cycloalkyl, C0-6alkylC3-6cycloalkenyl, C0-6alkylC3-6cycloalkenyl and C0-6alkylC3-6heterocyclyl may possibly be substituted with one or more D ; or ! two substituents R2, R3 or R4 together with the atoms to which they are attached may form a cyclic or heterocyclic ring, possibly substituted with one or more D; ! R5 is independently selected from hydrogen, cyano, OR6, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C0-6 alkylaryl, C0-6 alkyl heteroaryl, C0-6 alkyl C3-6 cycloalkyl, C0-6 alkyl C3-6 cycloalkenyl, C0-6 alkylC3-6 cycloalkenyl, C0- 6alkylC3-6heterocyclyl, CONR6R7, CO2R6, CO