STRAIN ENTEROCOCCUS FAECIUM LVP1073, PRODUCER OF BACTERIOCIN AGAINST BACTERIAL PATHOGENS, BACTERIOCIN E1073 AGAINST BACTERIAL PATHOGENS, STRAIN LACTOBACILLUS PLANTARUM 1 LVP7 - INDUCTOR OF BACTERIOCIN E1073 SYNTHESIS, SIGNAL PEPTIDE SP1073- REGULATOR OF BACTERIOCIN E1073 SYNTHESIS, METHOD FOR PRODUCING BACTERIOCIN E1073

摘要

FIELD: medicine.;SUBSTANCE: Enterococcus faecium LVP 1073 strain is deposited in the Collection of Microorganisms of the State Research Centre of Applied Microbiology and Biotechnology, Collection No. B-5736 - a producer of bacteriocin E1073 active against bacterial pathogens. The strain is recovered from the blind gut contents of a 42-day healthy broiler. Produced bacteriocin E1073 belongs to cation peptides (pi 8.2) and has molecular weight 3256 Da, consists of 34 amino acids. Presented is Lactobacillus plantarum 1 LVP7 strain deposited in the Collection of Microorganisms of the State Research Centre of Applied Microbiology and Biotechnology, Collection No. B-5943 - a bacteriocin E1073 synthesis inducer. Presented is a specific signal peptide SP1073, a bacteriocin E1073 synthesis regulator, recovered from a culture medium of a bacteriocin producing E.faecium LVP 1073 strain. Use of bacteriocin E 1073 for lifetime finish processing of poultry promotes production of pathogen-free and safe carcasses.;EFFECT: invention provides in vitro manifested antagonist activity against a number of gram-positive and gram-negative pathogens, including gram-positive spore-forming clostridia, gram-negative campilobacteria and salmonellas.;6 cl, 10 tbl, 7 ex