Ar1=Ar2=Ph, Ar3=C6H4Me-n (IIIa); and Ar1=C6H4Br-n, Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IIIb), for synthesis of methyl 6,9-diaryl-11-aroyl-2-(o-hydroxyphenyl)-3,4,10-trioxo-7-oxa-2,9-diazatricyclo[6.2.1.01,5]undec-6-ene-8-carboxylates of formula IV where Ar1=Ar2=Ph, Ar3=C6H4Me-n (IVa); Ar1=C6H4Br-n Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IVb), which exhibit antimicrobial activity and are used as precursors for synthesis of novel heterocyclic systems, and a method for synthesis of said compounds.;EFFECT: compounds have high effectiveness.;5 cl, 1 tbl, 5 ex"/>
INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO4,4NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO6.2.1.0<Sup>1,5</Sup>UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO 6.2.1.0<Sup>1,5</Sup>UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO 6.2.1.0<Sup>1,5</Sup>UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY
FIELD: chemistry.;SUBSTANCE: invention relates to novel intermediate compounds - methyl 7-aryl-4,9-diaroyl-3-hydroxy-1-(2-hydroxyphenyl)-2,6-dioxo-1,7-diazaspiro[4.4]none-3,8-diene-8-carboxylates of formula III Ar1=Ar2=Ph, Ar3=C6H4Me-n (IIIa); and Ar1=C6H4Br-n, Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IIIb), for synthesis of methyl 6,9-diaryl-11-aroyl-2-(o-hydroxyphenyl)-3,4,10-trioxo-7-oxa-2,9-diazatricyclo[6.2.1.01,5]undec-6-ene-8-carboxylates of formula IV where Ar1=Ar2=Ph, Ar3=C6H4Me-n (IVa); Ar1=C6H4Br-n Ar2=C6H4OEt-n, Ar3=C6H4Me-n (IVb), which exhibit antimicrobial activity and are used as precursors for synthesis of novel heterocyclic systems, and a method for synthesis of said compounds.;EFFECT: compounds have high effectiveness.;5 cl, 1 tbl, 5 ex
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机译：发明领域本发明涉及新型中间体化合物-甲基7-芳基-4,9-二氮酰基-3-羟基-1-（2-羟基苯基）-2,6-二氧代-1,7-二氮杂螺[4.4 ]式3的无3,8-二烯-8-羧酸酯<图像文件=“ 00000008.GIF” he =“ 46” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 78” /> Ar 1 = Ar 2 = Ph，Ar 3 = C 6 H 4 Me-n（ IIIa）;和Ar 1 = C 6 H 4 Br-n，Ar 2 = C 6 H 4 OEt-n，Ar 3 = C 6 H 4 Me-n（IIIb），合成6,9-二芳基-11-芳酰基-2-（邻羟基苯基）-3,4,10-三氧代-7-oxa-2,9-二氮杂三环[6.2.1.0 ]式IV的undec-6-ene-8-羧酸盐<图像文件=“ 00000010.GIF” he =“ 46” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 75” />其中Ar < Sup> 1 = Ar 2 = Ph，Ar 3 = C 6 H 4 Me- n（IVa）; Ar 1 = C 6 H 4 Br-n Ar 2 = C 6 H 4 OEt-n，Ar 3 = C 6 H 4 Me-n（IVb）抗菌活性，用作合成新型杂环系统的前体，以及所述化合物的合成方法。;效果：化合物具有很高的效力; 5 cl，1 tbl，5 ex
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