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method for the induction of terminal differentiation of development and memory b cells
method for the induction of terminal differentiation of development and memory b cells
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机译:诱导发育和记忆b细胞终末分化的方法
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摘要
The invention provides a method for promoting differentiation of a mature naïve B cell or a B cell progenitor into a memory B cell or a plasma cell. The method comprises (a) contacting a population of cells comprising a mature naïve B cell or a B cell progenitor with an agent that activates at least one of JAK1, JAK3, STAT3, STAT5A or STAT5B; wherein the population of cells optionally is contacted with an antigen, and (b) isolating the memory B cell or plasma cell.
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