首页>
外国专利>
Nucleic acid structure for inhibition or regulation of the functions of an immune response, its use in a process and immunologically compatible system containing this structure
Nucleic acid structure for inhibition or regulation of the functions of an immune response, its use in a process and immunologically compatible system containing this structure
展开▼
机译:用于抑制或调节免疫应答功能的核酸结构,其在含有该结构的过程和免疫相容系统中的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention provides a method for preparing an immunologically compatible system, e.g., organism, organ, tissue, or cells, by appropriate genetic intervention which can take the form of introducing into the cells of such a system, a nucleic acid construct which, when present in a cell, inhibits or regulates the function of an immune response (Ir) gene or genes in the system. The nucleic acid construct can be introduced, for example, in the form of genetic antisense or as antisense oligos. Also provided by the present invention is such a nucleic acid construct and an immunologically compatible system containing such a nucleic acid construct. When present in a cell, the nucleic acid construct inhibits or regulates the function of an immune response gene or genes in the system. This invention is useful and applicable in the field of therapeutics, and transplantation and transfusion methodologies.
展开▼