10-DEACETYL BACCATINE III AND 10-DEACETYL 14beta-HYDROXY BACCATINE III DERIVATIVE, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL FORMULATION CONTAINING THE SAME

摘要

PPROBLEM TO BE SOLVED: To provide new derivatives of 10-deacetyl baccatine III and 10-deacetyl 14-hydroxy baccatine III having cell toxicity and antitumoral activity. PSOLUTION: These derivatives are prepared starting from so-called synthon or other taxane of natural origin, by selective oxidation of hydroxy at site 10 to a keto functional group, and, if necessary, by following esterification of site 13 with variously substituted isoserine chains. The product, if appropriately prepared, can be administered by injection or orally. PCOPYRIGHT: (C)2011,JPO&INPIT