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Molecules containing bis (heteroaryl) maleimide backbones and their use in inhibiting DDE / DDD enzymes
Molecules containing bis (heteroaryl) maleimide backbones and their use in inhibiting DDE / DDD enzymes
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机译:含有双(杂芳基)马来酰亚胺骨架的分子及其在抑制DDE / DDD酶中的用途
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摘要
The invention concerns molecules with a bis-(heteroaryl)maleimide structure and having inhibiting characteristics with respect to enzymes with a catalytic pocket comprising the invariant amino acids D, D and E or D, D and D, such as transposases, RAG recombinases or retroviral integrases. The invention also concerns the use of said molecules for in vitro, ex vivo or in vivo inhibition of transposases, RAG recombinases and retroviral integrases such as HIV integrase, as well as the use of said molecules in the treatment of diseases associated with these enzymes in an animal or human host, in particular in the treatment of AIDS.
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