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IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF
IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF
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机译:G蛋白偶联受体EP3的新品种变异体的鉴定及其用途
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摘要
The present invention is directed to a polynucleotide sequence of the novel G-Protein Coupled Receptors EP3-11 OR EP3-12. The present invention provides polynucleotide sequences comprising the nucleic acid sequence SEQ ID NO: 20 or SEQ ID NO: 21 or nucleic acid sequences that hybridize to SEQ ID NO: 20 or SEQ ID NO: 21 or its complimentary strand having at least 40% sequence identity. The invention also provides the human EP3-11 or EP3-12 as targets for the identification of compounds useful for the treatment and prevention of cardiovascular diseases, inflammation, reproduction disorders and cancer as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds modulating EP3-11 or EP3-12.
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机译:本发明涉及新型G蛋白偶联受体EP3-11或EP3-12的多核苷酸序列。本发明提供了包含核酸序列SEQ ID NO:20或SEQ ID NO:21的多核苷酸序列,或与SEQ ID NO:20或SEQ ID NO:21或其具有至少40%序列的互补链杂交的核酸序列。身份。本发明还提供了人EP3-11或EP3-12作为靶标,用于鉴定可用于治疗和预防心血管疾病,炎症,生殖失调和癌症的化合物,这是相对定量不同人体组织中mRNA分布的结果通过表达分析。本发明还提供了用于鉴定调节EP3-11或EP3-12的化合物的测定法。
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