首页> 外国专利> HYPERBRANCHED POLYESTER AND A METHOD OF SYNTHESIZING A HYPERBRANCHED POLYESTER

HYPERBRANCHED POLYESTER AND A METHOD OF SYNTHESIZING A HYPERBRANCHED POLYESTER

机译:超支化聚酯和合成超支化聚酯的方法

摘要

The various embodiments herein provide a hyper branched polyester and a method of synthesizing the same. The embodiments herein also provide a method of encapsulating a drug into the void spaces of the polymer to act as a drug delivery system. The hyper branched polyester mer comprises an acidic moiety and an alcoholic moiety. The acidic moiety is citric acid monohydrate. The alcoholic moiety is glycerol. The acidic moiety and the alcoholic moiety are randomly arranged in the hyperbranched polymer. The method comprises of heating the mixture of citric acid and glycerol at temperatures of 90 to 150° C. by constant stirring for different time periods. In the method of encapsulation, the drug solution is drop-wise added to polymer solution at 37° C. by constant stirring for 24 h.
机译:本文的各种实施方案提供了超支化聚酯及其合成方法。本文的实施方案还提供了将药物包封在聚合物的空隙中以充当药物递送系统的方法。超支化聚酯单体包含酸性部分和醇部分。酸性部分是柠檬酸一水合物。醇部分是甘油。酸性部分和醇部分无规地排列在超支化聚合物中。该方法包括通过在不同时间段持续搅拌而在90至150℃的温度下加热柠檬酸和甘油的混合物。在封装方法中,通过不断搅拌24小时,在37℃下将药物溶液滴加到聚合物溶液中。

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