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Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
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机译:使用呼吸测试评估细胞色素P450 2D6同工酶活性的方法和组成
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摘要
The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.
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机译:本发明总体上涉及一种通过呼吸测定法确定和评估个体哺乳动物受试者中与细胞色素P450 2D6同工酶(CYP2D6)相关的代谢能力的方法,其方法是确定 13 Sup> CO <受试者在静脉内或口服给予 13 Sup> C标记的CYP2D6底物化合物后呼出Sub> 2 Sub>。本发明可用作体内表型测定法,用于在呼出气中使用代谢物 13 Sup> CO 2 Sub>评估CYP2D6相关活性,并确定最佳给药剂量和给药时间CYP2D6底物化合物的制备。
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