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Generation of transgenic human soluble amyloid precursor protein alpha expressing mice
Generation of transgenic human soluble amyloid precursor protein alpha expressing mice
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机译:转基因人类可溶性淀粉样蛋白前体蛋白表达小鼠的产生
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摘要
The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
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