This invention relates to vitamin-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harboring the pathogenic cells, and to a method of preparation of the conjugates. The conjugate is of the general formulaB-L-Xwherein the group B is a vitamin, or an analog or a derivative thereof, that binds to a surface accessible vitamin receptor that is uniquely expressed, overexpressed, or preferentially expressed by a population of pathogenic cells, wherein the group L comprises a cleavable linker, and wherein the group X comprises a mitomycin compound, or an analog or a derivative thereof. An additional therapeutic agent, such as a chemotherapeutic agent, can be administered in combination with the conjugate.
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机译：维生素-丝裂霉素结合物本发明涉及维生素-丝裂霉素结合物，使用该结合物有选择地消除携带病原细胞的宿主动物中的病原细胞群的方法，以及该结合物的制备方法。共轭具有通式<？in-line-formulae description =“在线表达式” end =“ lead”？> B-L-X <？in-line-formulae description =“在线表达式” end =“ tail”？>其中B组是维生素或其类似物或衍生物，其结合由病原细胞群唯一表达，过表达或优先表达的表面可及的维生素受体，其中L组包含可裂解的接头，其中基团X包括丝裂霉素化合物或其类似物或衍生物。可以将其他治疗剂，例如化学治疗剂与缀合物组合施用。
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