Use of derivatives 17 beta - cyano - 18th - homo - 19 nor androst 4 Ene to prepare a Medicine in the form of deposits for parenteral Application of Deposit, as well as Medicines containing Derivatives of 17beta cyano - 18th - homo - 19 nor androst 4 Ene - - for the application parenteral

摘要

17b-ciano-18a-homo-19-nor-androst-4-eno derivative is a general chemical formula (1), which has a pregnancy activity, in which Z is selected from a group of substances including or two hydrogen atoms, nor and nnhs2r, R is hydrogen or C1-4 tar; R4 is hydrogen or halogen, also has; r6a, R6b is methylene or 1, 2-ethane or r6a is hydrogen, R6b is selected from the group of hydrogen, methyl and oxyethane, R7 is selected from the group of hydrogen, C1-4 tar, C2-3 and cyclopropene, or r6a is hydrogen, R6b and R7 are formed at the same time, or fail when a double connection is formed between C6 and C7; R9,R10 is hydrogen, or it will be invalid if it forms a double connection between C9 and C10; R15 and R16 are hydrogen, or they form methylene together; R17 is selected from the hydrogen, C1-4 hydrocarbon and propylene groups, including at least one R4, r6a, R6b, R7, R15 substitute, R16 and R17 are not equal to hydrogen or R6b and R7. If they form a double connection between C6 and C7, or if they form a double connection between C1 and C2, and include their solution, hydrate, stereoisomer, acoustic isomer, corresponding isomer and salt, then these R16 and R17 will fail. They can be used to produce deposited drugs for parents, such as drugs in the womb or vagina.For example, these compounds are in the form of intrauterine systems or vaginal rings. This document also deals with these systems themselves,General chemical formula (1) containing at least one compound,To prepare for the implementation of parent-child relationship, especially in the womb or vagina.