Derivatives of 6 - cicloamino - 2-thienyl - 3 - (pyridin-4-yl) imidazo 1,2-b pyridazine hydrochloride and cicloamino - 6 - 2 - furanil - 3 - (pyridin-4-yl) imidazo 1,2-b pyridazine hydrochloride, its preparation and its application in diseases that involve the casein kinase 1 and / or casein kinase 1 Delta

摘要

Claim 1: it is composed of general formula (1), wherein: R2 represents a sulfur group or a furan group, which is finally replaced by one or more substitutes selected from halogen atom and C1-6 tar group; R3 represents a hydrogen atom or a c1-3 tar group; nr4r5 or C1-4 tar group; A refers to c1-7 tar group finally replaced by one or two RA groups; B refers to c1-7 tar group finally replaced by RB group; l refers to nitrogen atom finally replaced by RC group or RD group, or carbon atom finally replaced by RE1 group and RD group or two re2 groups;the carbon atoms of A and B being optionally substituted with one or several Rf groups identical or different from each other; Ra, Rb and Rc are defined such that: two Ra groups can together form a C1-6 alkylene group; Ra and R can together form a bond or a C1-6 alkylene group; Ra and Rc can together form a bond or a C1-6 alkylene group; Rb and Rc can together form a bond or a C1-6 alkylene group; Rd represents a group selected from the hydrogen atom and C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-6, C1-6 alkylthio-C1-6 alkyl, C1-6 alkyloxy -6, C1-6 fluoroalkyl, benzyl, C1-6 hydroxyalkyl;RE1 represents a group-nr4r5 or a cyclic monoamine that may contain oxygen atoms. Choose one or more substitutes between fluorine atoms and C1-6, alcoxi C1-6, hydroxyl and 2re2 tar groups, and finally replace cyclic monoamine. They are composed of carbon atoms, connected with a cyclic monoamine that may contain oxygen atoms, and this cyclic monoamine is eventually replaced by one or more RF groups, which are the same or different; RF represents a C1-6 tar group, C1-6, c3-7, cycloquil-3-7, C1-6. C1-6-c1-6-tar c1-6-hydroxyc1-6C1-6 fluorine or phenyl fluorine; R4 and R5 represent a hydrogen atom or a group of C1-4 tar, cycloquilo c3-7, cycloquil c3-7-c1-6 tar, respectively; R7 and R8 represent a hydrogen atom or a group of C1-6 tar, respectively; they are in the base or salt state of an acid.