methods for producing an immunogenic composition, for enhancing the immunogenicity of a composition, for enhancing the immunogenicity of a vaccine composition, and for determining the amount of beta-cross structures in a vaccine composition, uses of beta-cross structures, and an immunogenic composition, subunit vaccine, and immunogenic composition

摘要

METHODS TO PRODUCE AN IMMUNOGENIC COMPOSITION, TO IMPROVE THE IMMUNOGENICITY OF A COMPOSITION, TO INTENSIFY THE IMMUNOGENICITY OF A VACCINE COMPOSITION, AND TO DETERMINE THE AMOUNT OF BETA-CROSS STRUCTURES, IN A CROSS-BODY STRUCTURE COMPOSITION, AN IMMUNOGENIC COMPOSITION, SUBUNITY VACCINE, AND, IMMUNOGENIC COMPOSITION The invention relates to new methods and means for providing proteinaceous substances, such as peptides, polypeptides, glycoproteins, lipoproteins and complex compounds comprising the former in combination with other substances, such as nucleic acids , membrane structures, carbohydrate structures, with e-crossed structures, which improve the immunogenicity of that proteinaceous substance. The resulting peptides, proteins, glycoproteins, etc., are preferably used in vaccines. The invention provides a method for producing an immunogenic composition comprising at least one peptide, polypeptide, protein, glycoprotein, and / or lipoprotein, comprising providing said composition with at least one p-cross structure. The invention also describes the use of e-crossed structures in the preparation of a vaccine for the prophylaxis of an infectious disease. The invention further provides a method for improving the immunogenicity of a composition comprising at least one peptide, polypeptide, protein, glycoprotein and / or lipoprotein, comprising contacting at least one of said peptide, polypeptide, protein, glycoprotein and / or lipoprotein with an agent e-crossed inductor, thus providing said composition with additional e-crossed structures.