process for preparing a rapamycin 42-ester compound, method for isolating crude rapamycin 42-ester boronate from the mother liquor, method for purifying a rapamycin 42-ester boronate, and cci-779 boronate

摘要

PROCESS TO PREPARE A 42-RAPAMICINE RAPAMYCIN BORONATE, COMPOSITE, METHOD FOR ISOLATING BROONATE OF 42 RAY RAPAMICINE BROONATE . A scalable process for the preparation of a rapamycin 42-ester is provided by reacting a rapamycin 42-ester boronate with a diol and purifying the crude rapamycin 42-ester by recrystallization and treatment with a diol. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.