specific binding protein, nucleic acid molecule, vector, host cell, human monoclonal antibody, method of determining insulin-ii growth factor (igf-1i) and insulin-like growth factor i (igf-1) level in a patient sample, use of the specifically binding protein, and, conjugated

摘要

SPECIFICALLY CONNECTIVE PROTEIN, NUCLEIC ACID MOLECLE, VECTOR, HOST CELL, HUMAN MONOCLONAL ANTIBODY, METHOD FOR DETERMINING THE INSULIN-LI GROWTH FACTOR TYPE (IGF-I) IGF II TYPE A PATIENT SAMPLE, USE OF THE SPECIFICALLY CONNECTION PROTEIN, AND, CONJUGATED. Binding proteins such as IGF-II targeting antibodies with IGF-1 cross-reactivity and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to IGF-II with cross-reactivity to IGF-1 are described. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to heavy and light chain contiguous sequences encompassing the framework regions and / or complementarity determining regions (CDR 39) are also discussed. s), specifically from FR1 to FR4 or CDR1 to CDR3.