c3-convertase inhibitors for prevention and treatment of age-related macular degeneration in patients with alternative complement factor h risks

摘要

C3-CONVERTASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION CORRELATED TO AGE IN PATIENTS WITH ALTERNATIVE RISKS OF COMPLEMENT FACTOR H. The present invention relates to methods to identify a patient at risk of developing AMD, by identifying the presence of polymorphism of Y402H or other, in risk alternatives in the complement factor H gene. The present invention also provides methods for the treatment of people with AMD or at risk of developing AMD, as a consequence of presenting the polymorphism of Y402H or other, in risk alternatives in the complement factor H gene.