method of selecting a compound, in vitro method of predicting the presence of metastatic cancer or aggressive cancer, method of determining in vitro the effectiveness of an anticancer treatment, selection kit, compound, method of treatment, method of prevention or treatment, use of a compound, method or use and use of the netrin-1 expression level

摘要

METHOD OF SELECTING A COMPOUND, IN VITRO METHOD OF FORECASTING THE PRESENCE OF METASTATIC CANCER OR AGGRESSIVE CANCER, METHOD OF IN VITRO DETERMINATION OF THE EFFICIENCY OF AN ANTICANCERIGANEOUS TREATMENT, TREATMENT, TREATMENT, COMPOSITION, USE OF A COMPOUND, METHOD OR USE AND USE OF THE NETRINA-1 EXPRESSION LEVEL. The object of the present invention relates to an in vitro method of selecting anticancer compounds based on the ability of these compounds to interact with the netrin-1 receptor and / or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The present invention also relates to a method of predicting the presence of aggressive or metastatic cancer or of determining the efficiency of an anti-cancer treatment based on measuring the level of expression of netrin-1. The present invention further comprises kits and compounds as a drug for the treatment of cancer such as metastatic breast cancer, with respect to over-expression of netrin-1 by tumor cells.